SUPPORT HEALTHY TESTOSTERONE LEVELS

Healthy testosterone supports energy, vitality, performance and overall well-being. Clinical research suggests Physta® Tongkat Ali helps support the body’s natural hormone production as men age.

Study Design: A randomized, double-blind, placebo-controlled multicentre study evaluated the effects of Physta® in 105 ageing men aged 50–70 years experiencing age-related testosterone decline. Subjects received 100 mg or 200 mg of Physta® daily for 12 weeks, with the objective of assessing hormonal support and quality of life. Researchers measured total testosterone, free testosterone, DHEA (a hormone precursor), ageing male symptom scores, fatigue and sexual well-being.

Key Outcomes

  • Significant increase in total testosterone versus placebo
  • Significant increase in free testosterone versus placebo
  • Significant increase in DHEA, a precursor involved in healthy hormone production
  • Benefits observed as early as 2 weeks at 200 mg/day
  • Improvements in fatigue, sexual well-being and age-related male symptoms
Ref: Chinnappan, S. M., George, A., Pandey, P., Narke, G., & Choudhary, Y. K. (2021). Effect of Eurycoma longifolia standardised aqueous root extract (Physta®) on testosterone levels and quality of life in ageing male subjects: A randomised, double-blind, placebo-controlled multicentre study. Food & Nutrition Research, 65.
Testosterone structure context

REDUCE STRESS LOAD & CORTISOL

Chronic stress can disrupt hormone balance, affecting recovery, mood and resilience. Physta® Tongkat Ali helps support a healthier stress response by promoting better testosterone-to-cortisol balance.

Study Design: A randomized, double-blind, placebo-controlled study involving 63 moderately stressed adults evaluated the effects of 200 mg/day of Physta® for 4 weeks. The study aimed to determine whether supplementation could improve stress hormone balance and mood state. Researchers measured salivary cortisol, testosterone and validated psychological mood parameters.

Key Outcomes

  • 37% higher testosterone compared with placebo
  • 16% lower cortisol compared with placebo
  • 11% reduction in tension
  • 12% reduction in anger
  • 15% reduction in confusion
Ref: Talbott, S. M., Talbott, J. A., George, A., & Pugh, M. (2013). Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition, 10(28).
Reduce Stress Load & Cortisol

IMPROVES MOOD & QUALITY OF LIFE

Mood and quality of life are influenced by hormone balance, physical comfort and emotional resilience. Physta® Tongkat Ali may help support emotional well-being and everyday vitality during periods of physiological change.

Study Design: A randomized, double-blind, placebo-controlled clinical trial involving 138 women aged 40–55 years with menopausal symptoms evaluated Physta® at 50 mg and 100 mg daily for 12 weeks. The study assessed the ingredient’s effect on menopause-related quality of life and mood, measuring MENQOL (Menopause-Specific Quality of Life), mood state profiles and symptom domains including physical and sexual well-being.

Key Outcomes

  • 33.9% reduction in total MENQOL score from baseline (P = 0.049)
  • 36.4% improvement in physical well-being domain (P = 0.046)
  • 36.3% improvement in sexual well-being domain (P = 0.043)
  • 38.6% reduction in total mood disturbance
  • Improvements in fatigue and depressive mood indicators
Ref: Muniandy, S., Yahya, H. M., Shahar, S., et al. (2025). Effect of Eurycoma longifolia water extract (Physta®) on menopausal quality of life and mood states. World Journal of Clinical Cases, 13(31).
Improves Mood & Quality of Life

ENERGY & VITALITY

Sustained energy depends on healthy stress adaptation, hormone balance and resilience—not stimulants alone. Physta® Tongkat Ali helps support the systems that contribute to daily vitality.

Study Design: A randomized, placebo-controlled clinical study involving 93 moderately stressed adults aged 25–65 years evaluated a formulation containing 50 mg Physta® plus multivitamins daily for 24 weeks. The objective was to assess improvements in quality of life, mood, energy and stress resilience. Researchers measured quality of life scores, emotional health, vigour, stress and immune-related biomarkers.

Key Outcomes

  • 15% reduction in stress, compared with 0.7% in placebo
  • Significant improvement in energy scores
  • Increased vigour after 12 weeks
  • Improved emotional well-being and overall quality of life
  • Significant increase in lymphocyte counts, supporting resilience under stress
Ref: George, A., Udani, J., Zainal Abidin, N., & Yusof, A. (2018). Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: A randomized placebo-controlled parallel study. Food & Nutrition Research, 62.
Energy and Vitality

IMPROVES STRENGTH & MUSCLE STRENGTH

Strength naturally declines with age, stress and reduced hormone output. Supporting healthy testosterone and recovery may help maintain physical performance, mobility and muscle function over time.

Study Design: A randomized, double-blind, placebo-controlled study involving 37 middle-aged men with ageing male symptoms evaluated the effects of 200 mg/day Physta® Tongkat Ali combined with exercise over 6 months. The study aimed to assess improvements in strength, physical performance and age-related symptoms. Measured outcomes included muscle strength and ADAM (Androgen Deficiency in Ageing Males) symptom scores.

Key Outcomes

  • 17% increase in muscle strength with exercise + Physta® Tongkat Ali, compared with 14% increase from exercise alone
  • 36.1% reduction in ageing male symptoms, compared with 27.2% reduction from exercise alone
  • Demonstrated additive support for physical performance and recovery
Ref: Leitão, A. E., de Carvalho Souza Vieira, M., Gomes, D. A., et al. (2021). Exercise associated or not to the intake of Eurycoma longifolia improves strength and cardiorespiratory fitness in men with androgen deficiency. Complementary Therapies in Clinical Practice, 42, 101301.
Improves Strength & Muscle

FERTILITY & SEXUAL HEALTH

Male reproductive health is closely linked to hormone balance, vitality and physiological function. Clinical evidence suggests Physta® Tongkat Ali may help support fertility parameters and sexual wellness naturally.

Study Design: An open-label clinical study evaluated 75 men with idiopathic infertility (average infertility duration of approximately 5 years) receiving 200 mg/day of Physta® for 3 months. The objective was to assess the effect of supplementation on male fertility outcomes. Researchers measured sperm concentration, motility, morphology and reproductive outcomes over the intervention period.

Key Outcomes

  • Significant improvements in sperm concentration
  • Improved sperm motility
  • Improved normal sperm morphology
  • 14.7% of couples achieved spontaneous pregnancy during the study period
  • Supported overall male reproductive function in previously subfertile subjects
Ref: Tambi, M. I., & Imran, M. K. (2010). Eurycoma longifolia Jack in managing idiopathic male infertility. Asian Journal of Andrology, 12(3), 376–380.
Fertility & Sexual Health

ANDROPAUSE

Age-related testosterone decline can affect energy, mood, performance and sexual well-being. Physta® Tongkat Ali helps support healthy hormonal ageing and quality of life in men.

Study Design: An open-label clinical study assessed 76 men aged 28–70 years with late-onset hypogonadism symptoms, receiving 200 mg/day of Physta® Tongkat Ali for 4 weeks. The objective was to evaluate the ingredient’s ability to support healthy testosterone status and reduce ageing male symptoms. Measured outcomes included testosterone levels and ageing male symptom profiles.

Key Outcomes

  • Men with ageing male symptom complaints reduced from 70% to 10%
  • Men with normal testosterone status increased from 35% to 91%
  • Improvements observed within just 4 weeks
  • Supported healthier ageing-related hormonal balance
Ref: Tambi, M. I., Imran, M. K., & Henkel, R. R. (2011). Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia, 44(S1), 226–230.
Andropause

MENOPAUSE

(Patent: US 11,058,737 B2)

Menopause can impact comfort, mood, vitality and overall quality of life. Clinical research suggests Physta® Tongkat Ali may help support well-being during this transition period.

Study Design: A randomized, double-blind, placebo-controlled clinical trial involving 138 women aged 40–55 years with menopausal symptoms evaluated 50 mg and 100 mg Physta® Tongkat Ali daily for 12 weeks. The study assessed menopause-related quality of life, mood and functional well-being using validated outcome measures including MENQOL and mood state assessments.

Key Outcomes

  • 33.9% reduction in total MENQOL score (P = 0.049)
  • 36.4% improvement in physical symptoms (P = 0.046)
  • 36.3% improvement in sexual well-being (P = 0.043)
  • 38.6% reduction in mood disturbance
  • Demonstrated meaningful support for menopause-related quality of life
Ref: Muniandy, S., Yahya, H. M., Shahar, S., et al. (2025). Effect of Eurycoma longifolia water extract (Physta®) on menopausal quality of life and mood states. World Journal of Clinical Cases, 13(31).
Menopause

IMMUNITY & ANTIVIRAL SUPPORT

(Patent: US 11,166,998 B2)

Immune resilience naturally changes with age and stress. Physta® Tongkat Ali has been shown to support adaptive immune function, helping the body stay better prepared for everyday immune challenges.

Study Design: A randomized, double-blind, placebo-controlled study involving 83 healthy middle-aged adults aged 40–59 years evaluated 200 mg/day of Physta® Tongkat Ali for 4 weeks. The objective was to assess immune-support effects, with researchers measuring immune cell populations including CD4+ T-cells, naïve immune cells, immunological vigor and immune age markers.

Key Outcomes

  • Significant increase in CD4+ T-helper cells
  • Significant increase in naïve immune cells
  • Improved immunological vigor scores versus placebo
  • Improved immune age by 4 years
  • Demonstrated support for adaptive immune resilience
Ref: George, A., Suzuki, N., Abas, A., et al. (2016). Immunomodulation in middle-aged humans via the ingestion of Physta® standardized root water extract of Eurycoma longifolia Jack. Phytotherapy Research, 30(4), 627–635.
Immunity & Antiviral Support

MICROBIOME HEALTH

A healthy gut microbiome supports digestion, immunity, metabolism and gut-brain communication. Early findings suggest Physta® Tongkat promising early microbiome-support potential.

Study Design: A preliminary human case study evaluated a healthy 55-year-old woman supplemented with 100 mg/day of Physta® for 30 days. Stool samples collected before and after supplementation were analysed using Precision Microbiome Profiling (PMP™), assessing microbial diversity, beneficial bacterial populations, SCFA-producing species and potentially undesirable microbial groups.

Key Outcomes

  • Improved microbial richness and diversity
  • Increased beneficial Bifidobacteria and Lactobacilli
  • Increased SCFA-producing bacteria including Faecalibacterium prausnitzii
  • Reduced Proteobacteria, associated with poorer gut balance
Ref: Reichelt, A.-G. G., Kandanur, P., George, A., & Chinnappan, S. M. (2025). Impact of Eurycoma longifolia (Physta®) on gut microbiome composition: A case study using precision microbiome profiling. South Asian Research Journal of Natural Products, 8(2), 192–200.
Microbiome Health

METABOLIC HEALTH

Metabolic health influences energy use, glucose balance and resilience to oxidative stress. Early research suggests Physta® Tongkat Ali may support key metabolic and physiological wellness pathways.

Study Design: Preclinical investigations have explored Physta®’s impact on metabolic health, including glucose regulation and kidney-related biomarkers under physiological stress conditions. Studies assessed insulin secretion, glucose uptake, oxidative stress markers, blood urea and serum creatinine, providing early evidence supporting metabolic wellness positioning.

Key Outcomes

  • Increased insulin secretion from pancreatic cells
  • Enhanced glucose uptake into insulin-sensitive cells
  • Reduced blood markers associated with kidney stress in preclinical models
  • Supported antioxidant and physiological resilience pathways
  • Early evidence supports metabolic wellness positioning, pending human confirmation
Refs:
(1) Imam, M. U., et al. (2017). Eurycoma Longifolia Jack Water Extract (Physta®) and its 4.3 Kilodalton Peptide Increase Insulin Secretion from Pancreatic Cells and Enhance Glucose Uptake in Insulin-Sensitive Cells, in Vitro. European Journal of Scientific Research, 147(2), 177–187.
(2) Chinnappan, S. M., et al. (2019). Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity in rats. Evidence-Based Complementary and Alternative Medicine, 2019.
Metabolic Health

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