WHAT IS KESUM?

Kesum (Persicaria minor @ Polygonum minus) is an indigenous plant of Malaysia and South East Asia, also known as ‘Pygmy Smart Weed’. Traditionally used to flavour soups and dishes, it is also consumed as a salad or ‘ulam’ for anti-aging (‘awet muda’), aiding digestion, alleviating dandruff and post-partum tonic.

BIOKESUM^® LEAF EXTRACT

BioKesum^® is a a natural, standardized water extract that can help improve cognitive health. The patented water-extract functions as an all-around anti-aging ingredient and has been shown to support acetylcholine availability*. Studies have shown that BioKesum^® support memory and executive function, improves brain markers in the brain such as Brain-derived neurotrophic factor (BDNF) and reduces negative mood profiles (anger, tension and anxiety).

_{‍*Acetylcholinesterase inhibition=IC50 of 0.0405 mg/ml with 68% inhibition (George at al., 2014).}

STANDARDIZATION IN BIOKESUM®

Standardization is a process where the beneficial compounds in the extract are quantified and controlled for consistency. Biokesum^® is standardized to total polyphenol content (TPC >100mg/GAE per g dE) and the powerful flavanol Quercetin-3-Glucoronide (Q3G >0.45%) that have been scientifically proven to support brain health and improve cognitive function.

WHY CHOOSE BIOKESUM® FOR BRAIN HEALTH AND ANTI-AGEING INGREDIENT?

HIGH IN ANTIOXIDANT

BioKesum^®  shows strong antioxidant properties² that slow the oxidative processes and free radical damage as demonstrated by:

CLINICAL STUDIES ON BIOKESUM^®

BioKesum^® possesses antioxidant and anticholinesterase activity and the ‘Barnes Maze’ study showed 100mg/kg of BioKesum^® did not show scopolamine induced deficit in learning and memory (equivalent to donepezil) and Gingko biloba². This effect is further validated in three clinical trials looking into cognitive function and memory in healthy subjects.

Studies showed that BioKesum^® support memory and executive function, improves brain markers in the brain such as Brain-derived neurotrophic factor (BDNF) and reduces negative mood profiles (anger, tension and anxiety).

_{*Acetylcholinesterase inhibition=IC50 of 0.0405 mg/ml with 68% inhibition (George at al., 2014).
‍}

Study 1: Lau et. al., 2020

Study 2: Shahar, et. Al, 2017

Study 3: Udani, 2013

References:
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¹ Maizura, M., Aminah, A. and Wan Aida, W. M. Total phenolic content and antioxidant activity of Kesum (Polygonum minus), ginger (Zingiber officinale) and turmeric (Curcuma longa) extract. International Food Research Journal 18: 529-534 (2011)

² George A, Ng CP, O’Callaghan M, Jensen GS, Wong HJ. In vitro and ex-vivo cellular antioxidant protection and cognitive enhancing effects of an extract of Polygonum minus Huds (LineminusTM) demonstrated in a Barnes Maze animal model for memory and learning. BMC Complement Altern Med, 2014 May 19;14;16.

Study 1: Lau H, Shahar S, Mohamad M, Rajab NF, Yahya HM, Din NC, Hamid HA. The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial. BMC Complement Med Ther. 2020 Oct 19;20(1):315.

Study 2: Yahya, Hanis & Shahar, Suzana & ISMAIL, SITI & Aziz, Ainor & Normah, Che Din & Abdul Hakim, Bibi Nabihah. (2017). Mood, Cognitive Function and Quality of Life Improvements in Middle Aged Women Following Supplementation with Polygonum minus Extract. Sains Malaysiana. 46. 245-254. 10.17576/jsm-2017-4602-09.Study 3: Jay K Udani, “Effects of SuperUlam on Supporting Concentration and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 238454, 10 pages, 2013. doi: 10.1155/2013/238454